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目的 探讨Ⅲa期非小细胞肺癌 (NSCLC)术后预防性照射的临床意义。方法 回顾性分析 2 5 0例Ⅲa期NSCLC患者术后放射治疗与未放射治疗的生存率及复发情况。其中术后放射治疗115例 ,未放射治疗 135例。肺鳞癌 136例 ,放射治疗 70例 ,未放射治疗 6 6例。肺腺癌 75例 ,肺鳞腺癌及其它类型 39例。结果 术后放射治疗 5年生存率为 2 4.3% ,未予放射治疗 5年生存率为14.2 % ,两组比较有显著差别 (P <0 .0 5 )。肺鳞癌术后放射治疗 5年生存率 (2 6 .7% )明显高于未放射治疗者 (14.6 % ) (P <0 .0 5 )。结论 能手术切除的Ⅲa期非小细胞肺癌术后应给予预防性照射 ,以期提高生存期
Objective To explore the clinical significance of prophylactic irradiation after stage IIIa non-small cell lung cancer (NSCLC). Methods We retrospectively analyzed the survival rate and recurrence rate of postoperative radiotherapy and non-radiotherapy in 250 patients with stage IIIa NSCLC. Of these, 115 patients received postoperative radiation therapy and 135 had no radiation therapy. There were 136 cases of squamous cell carcinoma of the lung, 70 cases of radiation therapy, and 66 cases of no radiation therapy. There were 75 cases of lung adenocarcinoma, 39 cases of lung squamous cell carcinoma and other types. Results The 5-year survival rate of postoperative radiotherapy was 24.3%. The 5-year survival rate without radiotherapy was 14.2%. There was a significant difference between the two groups (P < 0.05). The 5-year survival rate of postoperative radiotherapy for lung squamous cell carcinoma (26.7%) was significantly higher than that of non-radiotherapy (14.6%) (P < 0.05). Conclusion Prophylactic irradiation should be given after surgical resection of stage IIIa non-small cell lung cancer in order to improve survival.