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多囊卵巢综合征(PCOS)是常见的生殖内分泌及代谢紊乱性疾病。通过对实验诱导的产前雄激素化的恒河猴和绵羊的观察,以及人类相关的数据的支持,得出结论:尽管PCOS是一个复杂的异质的疾病,但是其临床和生物学特征可以用卵巢雄激素产生的发育学起源所解释。胎儿的和(或)青春期的雄激素过剩重排下丘脑-垂体单元对黄体生成激素(LH)的控制,增加内脏脂肪分布,诱发胰岛素抵抗和无排卵,引起成年雄激素过多症的临床表现。其他的遗传和环境因素(尤其是饮食)可以与这个潜在的进程相互作用,修饰最终的表型,引起PCOS异质的特征。综述PCOS的发育学起源。
Polycystic ovary syndrome (PCOS) is a common reproductive and endocrine disorders and metabolic disorders. By observing the experimentally induced prenatal androgenic rhesus monkeys and sheep, as well as human-related data, we conclude that although PCOS is a complex heterogeneous disease, its clinical and biological characteristics can be Explained by the developmental origin of androgen production in ovaries. Fetal and / or adolescent androgen excess rearrange the hypothalamus-pituitary unit on luteinizing hormone (LH) control, increase visceral fat distribution, induce insulin resistance and anovulation, causing the clinical manifestations of adult androgen hyperactivity . Other genetic and environmental factors, especially diets, can interact with this potential process to modify the final phenotype, resulting in heterogeneous PCOS features. Summary PCOS developmental origin.