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目的探讨5种方案预防性治疗偏头痛的临床疗效,并进行药物经济学分析,为预防性治疗偏头痛提供经济、合理的治疗方案。方法采用回顾性研究方法,将200例偏头痛患者随机分为美托洛尔组(A组)、氟桂利嗪组(B组)、美托洛尔+氟桂利嗪组(C组)、头痛宁胶囊组(D组)、都梁软胶囊组(E组),每组各40例。采用成本-效果分析法并引入决策树模型,对5种治疗方案进行药物经济学评价。结果 A、B、C、D、E组的有效率分别为60.00%、72.50%、95.00%、45.00%、22.50%,总治疗成本分别为756.48、765.26、731.98、857.17、874.46元,成本-效果比(C/E)分别为12.61、10.56、7.71、19.05、38.86。其中,C组治疗方案的成本-效果比(C/E)最小,最具经济性。敏感性分析结果与最小成本分析结果相一致。结论在上述5种偏头痛预防性治疗方案中,美托洛尔+氟桂利嗪预防性治疗偏头痛更具成本-效果优势,是预防偏头痛较佳的治疗方案。
Objective To investigate the clinical efficacy of five kinds of prophylactic treatment of migraine headache, and to carry out the analysis of pharmacology and economics, to provide an economical and reasonable treatment plan for the preventive treatment of migraine. Methods 200 cases of migraine were randomly divided into metoprolol group (group A), flunarizine group (group B), metoprolol + flunarizine group (group C) and retrospective study method , Toutongning capsule group (D group) and Duliang soft capsule group (E group), 40 cases in each group. Cost-effectiveness analysis and the introduction of decision tree model, the five kinds of treatment programs for the evaluation of pharmacoeconomics. Results The effective rates of groups A, B, C, D and E were 60.00%, 72.50%, 95.00%, 45.00% and 22.50%, respectively. The total treatment costs were 756.48, 765.26, 731.98 and 857.17, respectively, (C / E) were 12.61,10.56,7.71,19.05,38.86. Among them, the C group treatment cost-effect ratio (C / E) the smallest, most economical. Sensitivity analysis results are consistent with the results of the minimum cost analysis. Conclusions Metoprolol + flunarizine prophylaxis for migraine is more cost-effective in the five migraine prophylaxis regimens mentioned above, and is a better treatment for migraine.