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对２３例浅表膀胱癌术后患者，用大剂量丝裂霉素（４０ｍｇ）加生理盐水４０ｍｌ稀释，膀胱内灌注预防浅表膀胱癌复发。平均随访２２个月，复发率为４．１％（１／２３）。研究表明：大剂量丝裂霉素膀胱内灌注，具有疗效好、不良反应少、使用安全方便的优点。比文献报道用小剂量丝裂霉素（１０～２０ｍｇ）疗效高，与卡介苗膀胱内灌注疗效基本相同，值得提倡使用。
Twenty-three patients with superficial bladder cancer were treated with high-dose mitomycin (40mg) and normal saline (40ml). Intravesical instillation was performed to prevent the recurrence of superficial bladder cancer. With an average follow-up of 22 months, the recurrence rate was 4.1% (1/23). Studies have shown that: high dose mitomycin intravesical instillation, with good efficacy, fewer adverse reactions, the advantages of safe and convenient use. Than reported in the literature with a small dose of mitomycin (10 ~ 20mg) high efficacy, and intra-BCG perfusion basically the same, it is worth promoting.