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Objective: To investigate the effects of probiotics on trimethylamine oxide, serum inflammatory markers, cardiac function and daily life in patients with chronic heart failure. Methods: Randomly selected from Mianyang Central Hospital in January 2019 - December 2019, by using random Numbers table is divided into control group and treatment group, control group with conventional western medicine therapy (strong heart, diuresis and expand blood vessels), treatment group using group (conventional western medicine treatment + probiotics), 12 weeks after treatment of chronic heart failure (CHF) in patients with cardiac function in left ventricular ejection fraction (LVEF) and cardiac volume index (LVEDVI), left ventricular end systolic volume index (LVESVI); Intestinal flora metabolite TMAO; Serum inflammatory markers were tumor necrosis factor - (TNF-) and c-reactive protein (CRP). Quality of life score (ADL), indexes of 6min walking experiment and changes before treatment. Results: After treatment, cardiac function (LVEDVI, LVESVI, LVEF) in both groups was higher than that before treatment. Plasma TMAO, serum inflammatory indicators TNF--, CRP, daily life quality score, and 6min walking test were significantly improved (p < 0.05). The expression levels of TMAO, TNF-, and CRP in the treatment group were significantly lower than those in the control group, with statistically significant differences (p < 0.05), while the ADL score and 6MWT were significantly higher than those in the control group, with statistically significant differences (p 0..05). Conclusion: Probiotics can correct intestinal flora disorder, control TMAO secretion, inhibit inflammatory response, and effectively improve the quality of life of patients. But it cannot repair damaged cardiomyocytes and heart function.