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目的:探讨血浆一氧化氮水平在酒精性心肌病患者病情评估中的作用。方法:对32例酒精性心肌病患者(ACM组)及30例扩张型心肌病患者(DCM组)进行NYHA分级,行超声心动图检查评估左心室舒张末期内径和左室射血分数,检测血浆一氧化氮水平,并将一氧化氮与NYHA分级、左心室舒张末期内径和左室射血分数行相关性分析。结果:ACM组血浆一氧化氮水平明显低于DCM组(P<0.01)。ACM组血浆一氧化氮水平NYHAⅣ级明显低于NYHAⅢ级,NYHAⅢ级明显低于NYHAⅡ级患者,差异均有统计学意义(P<0.01)。酒精性心肌病患者血浆一氧化氮水平与左心室舒张末期内径呈负相关(r=-0.90,95%CI为-0.80~-0.95,P<0.01),与左室射血分数呈正相关(r=0.88,95%CI为0.76~0.94,P<0.01)。结论:酒精性心肌病患者血浆中一氧化氮水平与病情严重程度密切相关。
Objective: To investigate the role of plasma nitric oxide in the evaluation of patients with alcoholic cardiomyopathy. Methods: NYHA classification was performed in 32 patients with alcoholic cardiomyopathy (ACM group) and 30 patients with dilated cardiomyopathy (DCM group). The left ventricular end-diastolic diameter and left ventricular ejection fraction were evaluated by echocardiography. Plasma Nitric oxide levels, and nitric oxide and NYHA classification, left ventricular end-diastolic diameter and left ventricular ejection fraction correlation analysis. Results: The level of plasma nitric oxide in ACM group was significantly lower than that in DCM group (P <0.01). The level of plasma nitric oxide in NYHA Ⅳ in ACM group was significantly lower than that in NYHAⅢand NYHAⅢ was significantly lower than that in NYHAⅡgroup (P <0.01). Plasma NO levels in patients with alcoholic cardiomyopathy were negatively correlated with left ventricular end-diastolic diameter (r = -0.90, 95% CI -0.80 to -0.95, P <0.01) and positively correlated with left ventricular ejection fraction (r = 0.88, 95% CI 0.76 to 0.94, P <0.01). Conclusion: The plasma nitric oxide level in patients with alcoholic cardiomyopathy is closely related to the severity of the disease.