患者女,36岁。咽下时梗堵感,消瘦1年,症状逐渐加重。入院时仅可进半流质,体重明显下降。入院前3个月始有时呕吐酸性白色液体。查体:面部及四肢皮肤发硬,指趾变尖发硬。口裂小,薄唇,鹰鼻,面部表情呆板。心、肺、腹未见阳性体征。食道钡餐:下段近贲门处5cm 范围呈环形狭窄,钡剂通过缓慢,管壁僵硬粘膜欠规则,诊断食管下段癌。食道内窥镜检查:距门齿32cm 食道下端前后壁粘膜充血、 Female patient, 36 years old. Swallowing infarction sense, weight loss for 1 year, the symptoms gradually increased. Admission can only enter the semi-liquid, weight decreased significantly. 3 months before admission sometimes vomit acidic white liquid. Physical examination: facial and limbs, hair hard, Zhi Zhi Zhi Jian hard. Small mouth, thin lips, eagle nose, facial expression dull. Heart, lung, abdomen no positive signs. Esophageal barium meal: the lower part of the cardia near the 5cm showed a ring-shaped narrow barium through the slow, rigid wall mucosal rules, the diagnosis of esophageal cancer. Esophageal endoscopy: 32cm from the incisors before and after esophageal mucosal congestion,