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采用酶标免疫组织化学法（ＡＢＣ法）分析妊高征患者及正常产妇胎盘中一氧化氮合成酶Ⅲ（ＮｉｔｒｉｃＯｘｉｄｅＳｙｎｔｈｅｔａｓｅ，ＮＯＳ３）的表达及分布。结果表明：ＮＯＳ３阳性染色颗粒位于合体滋养层细胞及血管内皮细胞胞浆内，ＮＯＳ３染色阳性率正常产妇组为（２１．６５±５．４４）％，妊高征组较正常产妇组明显升高，轻中度为（４３．２６±５．０７）％，重度为（５０．１４±５．１１）％，且轻中度与重度患者间有显著性差异（Ｐ＜０．０５）。提示：ＮＯＳ３浓度的升高，可能是妊高征病程中的一种保护性机制或代偿反应。
The expression and distribution of nitric oxide synthase Ⅲ (NOS3) in placenta of patients with pregnancy induced hypertension and normal maternal pregnancy were analyzed by enzyme-linked immunohistochemistry (ABC method). The results showed that the NOS3-positive staining particles were located in the syncytiotrophoblasts and the cytoplasm of vascular endothelial cells, the positive rate of NOS3 staining was (21.65 ± 5.44)% in the normal pregnant women group, significantly higher than that of the normal pregnant women in the PIH group , Mild to moderate (43.26 ± 5.07)% and severe (50.14 ± 5.11)%, respectively. There was a significant difference between mild to moderate and severe patients (P <0.05). Tip: NOS3 concentration may be a protective mechanism during pregnancy-induced hypertension syndrome or compensatory response.