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观察了不同浓度的辣椒素 (CAP)注入大鼠膀胱后 ,膀胱内压、膀胱容量的泌尿动力学变化及CAP对膀胱壁内含CGRP及NPY免疫反应性 (IR)神经的影响。结果发现 ,高浓度CAP(4mmol/L及 8mmol/L)处理后膀胱最大压力明显下降 ,而膀胱容量及残余尿量增加 (P 0 .0 1)。免疫组织化学发现 ,各种浓度的CAP均明显降低膀胱壁各层CGRP IR神经纤维的长度和密度 (P 0 .0 0 1)。结果表明 ,CAP能广泛耗竭膀胱组织内CAP敏感的一级传入神经末梢中的CGRP ,并表现出一定的浓度依赖性变化 ,此可能为降低膀胱内压 ,引起尿潴留和充溢性尿失禁的神经原性病理机制。这可能为临床上局部使用CAP治疗神经原性膀胱 (逼尿反射亢进 )、缓解尿频尿急提供理论依据
The effects of different concentrations of capsaicin (CAP) on urinary bladder pressure and urinary bladder volume, and the effect of CAP on CGRP and NPY immunoreactive (IR) nerve in the bladder wall were observed. The results showed that the maximal pressure of the bladder was significantly decreased while the volume of the bladder and residual urine were increased (P 0 .0 1) after high concentration of CAP (4mmol / L and 8mmol / L). Immunohistochemistry showed that various concentrations of CAP significantly decreased the length and density of CGRP IR nerve fibers in the bladder wall (P 0 .0 01). The results showed that CAP extensively depleted CGRP in CAP-sensitive primary afferent nerve endings in the bladder tissue and showed a concentration-dependent change that may be associated with reduced bladder pressure, urinary retention, and overflow incontinence Neurogenic pathology. This may provide a theoretical basis for the clinical use of CAP for the treatment of neurogenic bladder (detrusor hyperreflexia), relieve urinary frequency and urgency