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目的探讨雷贝拉唑联合铝镁加混悬液治疗活动性溃疡的临床疗效。方法选取常州市武进人民医院消化内科2014年2月—2016年8月收治的活动性溃疡患者144例,采用随机数字表法分为对照组(n=68)和观察组(n=66)。患者入院后均给予对症治疗,对照组患者给予雷贝拉唑治疗,观察组患者在对照组基础上联合铝镁加混悬液治疗,两组患者均持续治疗8周。比较两组患者胃镜疗效、临床症状改善情况、治疗前后血清白介素2(IL-2)、C反应蛋白(CRP)、胃泌素水平、症状积分,观察患者幽门螺杆菌(Hp)转阴率及不良反应发生情况。结果观察组患者胃镜检查总有效率高于对照组(P<0.05)。观察组患者症状治疗总有效率高于对照组(P<0.05)。治疗前,两组患者IL-2、CRP、胃泌素水平及症状积分比较,差异无统计学意义(P>0.05);治疗后,观察组患者IL-2水平高于对照组,CRP、胃泌素水平及症状积分低于对照组(P<0.05)。观察组患者Hp转阴率高于对照组(P<0.05)。两组患者均未出现严重不良反应。结论采用雷贝拉唑联合铝镁加混悬液治疗活动性溃疡的临床疗效肯定,可加速溃疡愈合,提高症状控制效果,降低炎性反应,且安全性好。
Objective To investigate the clinical efficacy of rabeprazole combined with aluminum-magnesium plus suspension in the treatment of active ulcer. Methods A total of 144 patients with active ulcer admitted to Department of Gastroenterology, Wujin People ’s Hospital of Changzhou from February 2014 to August 2016 were randomly divided into control group (n = 68) and observation group (n = 66). All patients were given symptomatic treatment after admission. Patients in the control group were treated with rabeprazole. Patients in the observation group were treated with aluminum-magnesium plus suspension on the basis of the control group. Both groups were treated for 8 weeks. Gastroscopy curative effect, clinical symptom improvement, serum interleukin 2 (IL-2), C-reactive protein (CRP), gastrin level and symptom score before and after treatment were compared between the two groups, and the negative rate of Helicobacter pylori (Hp) Adverse reactions occurred. Results The total effective rate of gastroscopy in observation group was higher than that in control group (P <0.05). The total effective rate of symptom treatment in observation group was higher than that in control group (P <0.05). Before treatment, IL-2, CRP, gastrin and symptom scores of two groups had no significant difference (P> 0.05). After treatment, the level of IL-2 in observation group was higher than that in control group The scores of the levels and symptoms were lower in the control group (P <0.05). The Hp negative rate in observation group was higher than that in control group (P <0.05). No serious adverse reactions occurred in both groups. Conclusion The clinical efficacy of rabeprazole combined with aluminum-magnesium plus suspension in the treatment of active ulcers certainly accelerates the healing of ulcers, improves the effect of symptom control, reduces the inflammatory reaction and has good safety.