Objective:To determine resistance status ofCulex species to different class of insecticides and assess the major anti-mosquito strategies employed by urban households and their possible effects on malaria acquisition. Methods:Structured questionnaires were randomly administered to obtain information on demographic characteristics, measures that people use to prevent mosquito bites and their perception of where mosquitoes breed in their communities.Adult susceptibility assays were also carried out usingWHO discriminating dosages of four insecticides from different chemical classes againstCulex species.Results:Majority of respondents(54.75%) preferred the use of domestic insecticides in the form of aerosols and coils.Among households that used domestic insecticides, the use of coil was most frequent(62.9%) with a mean(95%CI) of9.18(8.99,9.37) coils per week.Strong level of pyrethroid-resistance and multiple insecticide resistance inCulex species were also detected in some of the study sites.Conclusions:The excessive use of domestic insecticides and high level of resistance inCulex species observed in the study area has implications for theITN component of the nation’s malaria control program in more subtle ways.People will lose interest in the use ofITN when it fails to protect users from bites of resistantCulex species.Excessive use of domestic insecticides may also select resistance in both malaria vectors andCulex species.On this account we recommend that nuisance mosquitoes must be controlled as part of malaria control programs to improve acceptance and utilization ofITN.