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为了探讨长效雄激素替代治疗对克氏综合征患者垂体性腺轴系功能的影响及其治疗效果，本文选择６例１６ ～２６ 岁的克氏综合征患者，双侧深部肌肉注射国产十一酸睾酮（ Ｔ Ｕ）５００ ｍｇ，分别在注射前和注射后的１ 、２ 、３ 、４ 、６ 、８ 周末取外周血，用超灵敏的放射免疫法测定促性腺激素和性激素。结果表明，治疗后患者精神和体力提高，纳食量和体重略有增加，促进了第二性征发育。血平均睾酮（ Ｔ） 水平在 Ｔ Ｕ 注射后的第一周末从注射前的基础值２ ．７４ｎｍｏｌ／ Ｌ 提高到最大值的５１ ．０３ ｎｍｏｌ／ Ｌ，并持续在１０ ｎｍｏｌ／ Ｌ 水平以上达６ 周。而高 Ｆ Ｓ Ｈ、 Ｌ Ｈ 水平则被明显地抑制，且对 Ｌ Ｈ 的抑制作用较 Ｆ Ｓ Ｈ 更强。因此， Ｔ Ｕ 是克氏综合征患者替代治疗中较为理想的长效雄激素。
In order to investigate the effect of long-acting androgen replacement therapy on the function of gonadal axis system in patients with Klinefelter’s syndrome and its therapeutic effect, we selected 6 patients aged 16 to 26 years with Klinefelter’s syndrome, Acid testosterone (T U) 500 mg. Peripheral blood was taken before injection and at the end of 1, 2, 3, 4, 6, 8 weeks after injection. Gonadotropin and sex hormones were determined by ultrasensitive radioimmunoassay. The results showed that after treatment, patients with mental and physical improvement, food intake and weight increased slightly, and promote the development of secondary sexual characteristics. Blood mean testosterone (T) levels at the first weekend after T U injection ranged from 2 before baseline. 74nmol / L increased to a maximum of 51. 03 nmol / L, and continued at 10 nmol / L level for 6 weeks. While the high F S H and L H levels were significantly inhibited and the inhibitory effect on L H was stronger than F S H. Therefore, T U is the ideal long-acting androgen in Kirschner’s disease replacement therapy.