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目的:探讨产前孕妇凝血酶原时间(PT)、活化部分凝血活酶时间(a PTT)、凝血酶时间(TT)、纤维蛋白原(Fbg)及联合抗凝血酶(AT)、D-二聚体(D-D)检测的临床意义。方法:以2014年8月至2015年10月接受产前检查的180例孕妇为观察对象,同时选取180例未妊娠健康女性作为对照组。观察两组PT、a PTT、TT、Fbg水平和AT、D-D水平的差异。分析PT、a PTT、TT、Fbg水平与AT、D-D水平的相关性。结果:观察组孕妇的PT、a PTT、TT水平分别为(10.02±1.03)、(26.12±3.68)、(10.13±2.36)s,明显低于对照组,而Fbg水平为(4.89±0.35)g·L-1,明显高于对照组,差异均具有统计学意义(P<0.001);观察组孕妇的AT水平[(64.68±9.35)%]明显低于对照组(t=20.832,P<0.001),而D-D水平为(759.56±26.82)ng·ml-1,明显高于对照组,差异具有统计学意义(t=-23.286,P<0.001);AT与PT、a PTT和TT呈正相关,与Fbg水平呈负相关,D-D水平与PT、a PTT和TT呈负相关,与Fbg水平呈正相关,均P<0.05。结论:产前孕妇的PT、a PTT、TT和AT水平较低,Fbg和D-D水平较高,可作为临床监测的重要指标。
Objective: To investigate the relationship between pre-natal prothrombin time (PT), activated partial thromboplastin time (PTT), thrombin time (TT), fibrinogen (Fbg) and combined antithrombin (AT) Dimer (DD) detection of clinical significance. Methods: A total of 180 pregnant women undergoing prenatal examination between August 2014 and October 2015 were enrolled in this study. 180 healthy pregnant women were selected as the control group. The differences of PT, PTT, TT, Fbg levels and AT, D-D levels between the two groups were observed. The correlation between PT, PTT, TT, Fbg levels and AT and D-D levels was analyzed. Results: The PT, PTT and TT levels in the observation group were (10.02 ± 1.03), (26.12 ± 3.68) and (10.13 ± 2.36) s respectively, which were significantly lower than those in the control group (4.89 ± 0.35) g · L-1 was significantly higher than that of the control group (P <0.001). The level of AT in the observation group was significantly lower than that of the control group [(64.68 ± 9.35)%] (t = 20.832, P <0.001 ), While the level of DD was (759.56 ± 26.82) ng · ml-1, which was significantly higher than that of the control group (t = -23.286, P <0.001) Negatively correlated with Fbg level. DD level was negatively correlated with PT, PTT and TT, and positively correlated with Fbg level (all P <0.05). Conclusion: Prenatal pregnant women have lower levels of PT, PTT, TT and AT, higher levels of Fbg and D-D, which can be used as an important indicator of clinical monitoring.