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目的测定成都市褐家鼠种群对抗凝血类杀鼠剂的抗药性水平,为鼠害控制提供依据。方法采用凝血反应法测定褐家鼠对杀鼠灵和溴敌隆的抗药性。结果成都地区褐家鼠对杀鼠灵ED50为0.873(雄)和1.439(雌)mg/kg;对溴敌隆ED50为1.091(雄)和1.296(雌)mg/kg。按照鼠药抗性委员会推荐的敏感褐家鼠基准,该鼠种群对杀鼠灵的抗性水平在0.578～0.676之间;对溴敌隆的抗性水平在2.125～2.321之间。结论成都地区褐家鼠种群对溴敌隆已产生抗药性,对杀鼠灵未产生抗药性;在鼠害治理中,杀鼠灵可作为替代药物。
Objective To determine the resistance level of Rattus norvegicus to anticoagulant rodenticides in Chengdu, and to provide basis for rodent control. Methods The resistance of Rattus norvegicus to warfarin and bromadiolone was determined by coagulation reaction method. Results Rattus norvegicus had ED50 of 0.873 (male) and 1.439 (female) mg / kg for warfarin in Chengdu and ED91 of 1.091 (male) and 1.296 (female) mg / kg for bromadiolone respectively. According to the Rattus norvegicus recommendation of the Rattus norvegicus benchmark, the resistance of the mouse population to warfarin was between 0.578 and 0.676; the resistance to bromadiolone was between 2.125 and 2.321. Conclusion The populations of Rattus norvegicus in Chengdu have been resistant to bromadiolone and have no resistance to warfarin. In the rodent control, warfarin can be used as an alternative drug.