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目的探讨阿卡波糖联合盐酸二甲双胍对2型糖尿病(T2DM)患者血糖控制及生活质量的影响。方法选取河南省直第三人民医院2011年9月—2015年4月T2DM患者107例,按建档顺序分组,对照组53例予以盐酸二甲双胍治疗,研究组54例予以阿卡波糖联合盐酸二甲双胍治疗,两组均持续治疗84d。对比两组治疗前后血糖指标[空腹胰岛素(FINS)、空腹血糖(FBG)、饭后2h血糖(2 h BG)]及生活质量评分。结果治疗前两组FINS、FBG、2 h BG比较差异均无统计学意义(P>0.05),治疗后研究组FINS、FBG、2 h BG均低于对照组,差异均具有统计学意义(P<0.05);治疗前2组生活质量各项评分比较,差异均无统计学意义(P>0.05),治疗后研究组情感职能、躯体功能、总体健康等生活质量各项评分均高于对照组,差异均具有统计学意义(P<0.05)。结论阿卡波糖联合盐酸二甲双胍治疗T2DM患者,可显著改善其血糖水平及生活质量。
Objective To investigate the effect of acarbose plus metformin hydrochloride on blood glucose control and quality of life in patients with type 2 diabetes mellitus (T2DM). Methods Totally 107 patients with T2DM were enrolled in the Third People’s Hospital of Henan Province from September 2011 to April 2015. The patients in the control group were treated with metformin hydrochloride. In the study group, 54 patients were treated with acarbose plus metformin hydrochloride Treatment, both groups continued treatment 84d. The levels of blood glucose (fasting insulin (FINS), fasting blood glucose (FBG), 2h postprandial blood glucose (2h BG)] and quality of life before and after treatment were compared between the two groups. Results There were no significant differences in FINS, FBG and BG before 2 h of treatment (P> 0.05). The FINS, FBG and BG of 2 h after treatment were all lower than those of the control group (P <0.05). There was no significant difference in the scores of quality of life between the two groups before treatment (P> 0.05). After treatment, the scores of emotional function, physical function, general health and other quality of life in the study group were higher than those in the control group , The differences were statistically significant (P <0.05). Conclusion Acarbose combined with metformin hydrochloride in patients with T2DM can significantly improve their blood glucose levels and quality of life.