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目的 :探讨血清转化生长因子 β1 (TGF β1 )肾细胞癌侵袭性的作用。方法 :应用酶联免疫吸附试验 (ELISA)方法检测 17例正常人血清TGF β1 和 17例肾细胞癌病人根治术前后TGF β1 浓度。结果 :所有肾细胞癌根治术前病人血清TGF β1 浓度明显高于正常对照组 (P <0 .0 1) ,根治术后血清TGF β1 浓度明显下降 (P <0 .0 1)。结论 :血清TGF β1 浓度可能成为一种判断肾细胞癌预后的瘤标
Objective: To investigate the role of serum transforming growth factor-β1 (TGF-β1) in invasiveness of renal cell carcinoma. Methods: The serum levels of TGFβ1 in 17 normal human serum and 17 patients with renal cell carcinoma were detected by enzyme linked immunosorbent assay (ELISA). Results: The serum level of TGF-β1 in all patients with preoperative renal cell carcinoma was significantly higher than that in the normal control group (P <0.01). The serum TGF-β1 level decreased significantly after radical operation (P0.01). Conclusion: The serum concentration of TGF-β1 may be a tumor marker for predicting the prognosis of renal cell carcinoma