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Objective To observe the regulation of Fengxiaofang on the expression of gene Gob-5 in ovalbumin-challenged asthmatic mice.Methods The murine model of allergic asthma established by ovalbumin was used.The model mice were treated experimentally with Fengxiaofang and Dexamethasone as a positive control.The quantitive expression of gene Gob-5 in lung of mice was detected by real-time quantitative PCR.Results The expression of gene Gob-5 in lung of mice was down-regulated by Fengxiaofang.In the experiment,there were no significant differences between the one-fold or ten-fold dosage groups and the normal control group.Gene Gob-5 expression in five-fold dosage was significantly lower than that in the normal control group.Conclusion Fengxiaofang has the effect of lowering the expression of gene Gob-5 which maybe related to the potency on asthmatic disease.
Objective To observe the regulation of Fengxiaofang on the expression of gene Gob-5 in ovalbumin-challenged asthmatic mice. Methods The murine model of allergic asthma established by ovalbumin was used. The model mice were treated experimentally with Fengxiaofang and Dexamethasone as a positive control. The quantitive expression of gene Gob-5 in lung of mice was detected by real-time quantitative PCR. Results of the expression of gene Gob-5 in lung of mice was down-regulated by Fengxiaofang. The experiment, there were no significant differences between the one-fold or ten-fold dosage groups and the normal control group. Gene Gob-5 expression in five-fold dosage was significantly lower than that in the normal control group. Confluence Fengxiaofang has the effect of lowering the expression of gene Gob- 5 which maybe related to the potency on asthmatic disease.