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人类基因组计划的完成、功能基因组学和分子医学的建立和发展,促进了临床疾病基因研究的深入。女性盆底功能障碍作为一类多基因、致病因素和环境因素共同作用的常见疾病,运用基因组学理论及当代分子生物学技术,对其进行相应的基因研究具有明确的可行性,且对揭示其遗传易感性、阐明其发生发展的相关分子机制具有重要意义,有望为盆底功能障碍分子水平上的诊断、治疗、预防开辟新路径。本文就盆底功能障碍基因研究重要性、可行性、研究现状及展望等方面做一综述。
Completion of the Human Genome Project, the establishment and development of functional genomics and molecular medicine, and promote the depth of clinical disease gene research. Female pelvic floor dysfunction as a common multi-gene, pathogenic factors and environmental factors common disease, the use of genomics theory and contemporary molecular biology techniques, its corresponding gene research has clear feasibility, and to reveal Its genetic susceptibility, to clarify the occurrence and development of the relevant molecular mechanisms of great significance, is expected to molecular level of pelvic floor dysfunction diagnosis, treatment and prevention to open up new avenues. This article reviews the importance, feasibility, research status and prospects of the research on pelvic floor dysfunction genes.