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目的 :观察中药降脂方对红细胞膜胆固醇与磷脂比值 (Ch/ Pl)变化。方法 :用高脂饲料造成家兔实验性高血脂症模型 ,酶法测定胆固醇 (Ch) ,用分光光度法测定磷脂 (Pl)。实验设空白对照组、模型组、中药组和多烯康组。分别观察中药降脂方的降脂作用和对红细胞膜成分的影响。结果 :中药降脂方对高脂血症家兔有较好的降脂作用 ,红细胞膜 Ch/ Pl也有所下降。结论 :这项指标的建立对于临床高血脂、高血压、冠心病等疾病的监测和药物疗效的考察提供参考价值
Objective : To observe the change of ratio of cholesterol to phospholipid (Ch/Pl) in erythrocyte membrane of traditional Chinese medicine. METHODS: Experimental hyperlipidemia model in rabbits was induced with high-fat diet. Cholesterol (Ch) was determined by enzymatic method and phospholipid (P1) was measured by spectrophotometry. The experimental group was divided into blank control group, model group, Chinese medicine group and polyene group. Observe the lipid-lowering effect of traditional Chinese medicine Jiangzhi Recipe and its effect on red blood cell membrane components. Results: The traditional Chinese medicine Jiangzhi recipe had better lipid-lowering effect on hyperlipidemia rabbits, and Ch/Pl of red blood cell membrane also decreased. Conclusion : The establishment of this index can provide reference for the monitoring of clinical hyperlipidemia, hypertension, coronary heart disease and other drug effects.