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目的:探讨乌司他丁联合持续肾脏替代治疗(CRRT)的治疗作用以及对动脉血气指标的影响。方法:对20例脓毒性休克急性肾损伤患者进入ICU后给予支持治疗,随机分为两组,治疗组在CRRT治疗基础上加用乌司他丁治疗;对照组仅用CRRT进行治疗。比较两组患者动脉血气相关指标(PaO_2、PaCO_2)的上升程度。结果:治疗后48小时,治疗组PaO_2、PaCO_2值明显上升(p<0.05),与对照组比较,差异均有统计学意义(p<0.05)。结论:乌司他丁联合持续肾脏替代治疗(CRRT)的治疗对脓毒性休克急性肾损伤患者的PaO_2、PaCO_2指标有效升高,提高疗效。
Objective: To investigate the therapeutic effect of ulinastatin combined with continuous renal replacement therapy (CRRT) and its effect on arterial blood gas index. Methods: Twenty patients with septic shock and acute kidney injury were enrolled in the ICU and were randomly divided into two groups. The treatment group was treated with ulinastatin on the basis of CRRT treatment. The control group was treated with CRRT alone. The arterial blood gas related index (PaO_2, PaCO_2) of two groups were compared. Results: PaO_2 and PaCO_2 in treatment group increased significantly (p <0.05) 48 hours after treatment, and the difference was statistically significant (p <0.05) compared with control group. Conclusion: The combination of ulinastatin and continuous renal replacement therapy (CRRT) can effectively increase PaO_2 and PaCO_2 in patients with acute renal injury induced by septic shock and improve the curative effect.