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ICS205-930([IH]-吲哚-3-碳酸茛菪酯盐酸盐)是新近合成的一种化合物,对末梢神经5-HT 兴奋性受体(5-HT_3受体)有强烈的高选择性阻断作用。在体外,ICS205-930能提高电场刺激而加强豚鼠的胃排空。并对动物呕吐模型有强烈镇吐作用。本研究通过静脉给予10mg 和20mg 的 ICS205-930,评价该药对正常自愿受试者固体食物胃排空的影响。方法 12名正常志愿受试者,男,女各6名,年龄21～28岁,不吸烟,未服用任何药物,无任何胃肠
ICS205-930 ([IH] -indole-3-carbonate) is a newly synthesized compound with a strong preference for 5-HT excitatory receptors (5-HT 3 receptors) on the peripheral nerves Sexual blockade. ICS205-930 enhances gastric emptying in guinea pigs in vitro by increasing electrical stimulation. And the animal model of vomiting has a strong antiemetic effect. This study evaluated the effect of this drug on gastric emptying of solid food in normal volunteers by intravenously administering 10 mg and 20 mg of ICS205-930. Methods Twelve normal volunteers, 6 males and 6 females, aged 21-28 years old, non-smoking, without any medication, without any gastrointestinal