脑胶质瘤是神经外科常见疾病之一 ,而肿瘤的侵袭和转移往往是患者肿瘤复发、治疗失败和死亡的重要原因。肿瘤的侵袭过程是瘤细胞从原发瘤脱离后向周围组织侵袭的过程 ,是肿瘤细胞通过细胞膜表面受体粘附到细胞外基质 (ｅｘｔｒａｃｅｌｌｕａｒｍａ ｔｒｉｘ ,ＥＣＭ )并穿过细 Glioma is one of the common diseases of neurosurgery, and the invasion and metastasis of the tumor are often the important reasons of tumor recurrence, treatment failure and death in patients. Tumor invasion is the process by which the tumor cells invade the surrounding tissue after they have detached from the primary tumor. The tumor cells adhere to the extracellular matrix (ECM) through the cell surface receptors and pass through the fine