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目的:观察开口箭皂苷对实验性高脂血症小鼠血脂代谢的影响及对胆固醇吸收的抑制作用。方法:给小鼠灌食高脂乳剂,并设空白对照、模型对照、洛伐他汀阳性对照、地奥心血康剂量组和开口箭皂苷治疗组。分别测定血脂生化指标,检测药物对离体胆固醇微胶粒形成的抑制作用,并在光镜下观察主动脉的病变情况。结果:与模型组比较,灌食与腹腔注射开口箭皂苷均能明显降低血清TC、LDL-c及TC/HDL-c和LDL-c/HDL-c,亦能显著升高HDL-c;高剂量治疗组病理检查可见主动脉粥样硬化症状明显减轻;且开口箭皂苷可在一定程度上抑制肠道中胆固醇微胶粒的形成。结论:开口箭皂苷能治疗实验性高脂血症,抑制胆固醇微胶粒与动脉粥样硬化斑块的形成。
OBJECTIVE: To observe the effect of triterpene saponin on blood lipid metabolism and inhibition of cholesterol absorption in experimental hyperlipidemic mice. METHODS: Mice were fed with high-fat emulsion and blank control, model control, lovastatin positive control, Dioxin Xuekang dose group, and open saponin treatment group. The biochemical indexes of blood lipids were measured, and the inhibitory effect of drugs on the formation of isolated cholesterol micelles was examined. The lesions of aorta were observed under light microscope. RESULTS: Compared with the model group, both gavage and intraperitoneal injection of saponin significantly reduced serum TC, LDL-c, TC/HDL-c and LDL-c/HDL-c, and also significantly increased HDL-c; The pathological examination of the dose treatment group showed that atherosclerotic symptoms of the aorta were significantly reduced; and aldosterone can inhibit the formation of cholesterol micro-colloids in the intestinal tract to a certain extent. CONCLUSIONS: Tapioca saponins can treat experimental hyperlipidemia and inhibit the formation of cholesterol microparticles and atherosclerotic plaques.