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目的:分析万古霉素致药物不良反应(ADR)的原因与特点,为临床规范合理使用万古霉素提供参考。方法方法:利用万方数据库,检索“万古霉素”“不良反应”为检索词,剔除同一病例不同文献的重复的以及病例资料不全的文献,筛选出41例万古霉素致不良反应病例文献,并对其ADR发生的原因和特点作了分析。结果:万古霉素导致不良反应主要有变态反应(48.78%)、肾毒性(14.63%)、白细胞减少(12.20%)等;另有肝损害、第8脑神经、皮肤黏膜综合征、四肢颤抖等也有报道。结论:万古霉素致不良反应较多,应规范其用法用量及对可能出现的不良反应进行监测。
Objective: To analyze the causes and characteristics of vancomycin-induced adverse drug reactions (ADRs) and provide references for the rational use of vancomycin in clinical practice. Methods and Methods: With the help of Wanfang database, searching “vancomycin” and “adverse reactions” as the search terms, we eliminated the duplication and incomplete cases of different documents in the same case and screened out 41 cases of vancomycin-induced adverse reactions Response to case literature, and its ADR causes and characteristics were analyzed. Results: The main adverse reactions caused by vancomycin were allergic reaction (48.78%), nephrotoxicity (14.63%) and leucopenia (12.20%). Other liver damage, 8th nerve, mucocutaneous mucosa syndrome, There are also reports. Conclusion: vancomycin caused more adverse reactions, the dosage should be standardized and the potential adverse reactions should be monitored.