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本文主要叙述乙型肝炎病毒感染患者发展成慢性活动性肝炎(CAH)的可能机理。肝炎病毒感染后可引起各种不同的结果。多数患者发生典型的急性病毒性肝炎,从发病到完全恢复需时3～8周。少数患者迅速发展成暴发型肝功能衰竭,死亡率达80%以上。有一些急性肝炎患者,尽管清除了病毒,但炎症持续数月,这些患者被证明已产生 CAH 的临床和组织学表现。约30%的 CAH 病例没有急性病毒性肝炎的过去史。平滑肌抗体和抗核抗体阳性,血清球蛋白增高,肝内浆细胞和单核细胞的浸润都说
This article describes the possible mechanisms for the development of chronic active hepatitis (CAH) in patients with hepatitis B virus infection. Hepatitis virus infection can cause a variety of different results. Most patients with typical acute viral hepatitis, from onset to complete recovery takes 3 to 8 weeks. A small number of patients rapidly developed into fulminant hepatic failure, the mortality rate of 80% or more. In some patients with acute hepatitis, the inflammation persists for months despite clearance of the virus and these patients have demonstrated clinical and histologic findings of CAH. Approximately 30% of CAH cases have no past history of acute viral hepatitis. Smooth muscle antibodies and antinuclear antibodies positive, elevated serum globulin, intrahepatic plasma cells and mononuclear cell infiltration are said