混合性结缔组织病(Mixed Connective Tissue Disease简称为MCTD)系近年来发现的一种免疫复体病,具有与其他结缔组织病类似的免疫学改变,因而归属于系统性自身免疫性疾病的范畴。Sharps等于1971年发现了这一病种,旋于1972年首先报道并加以命名,以后报告日见增多。由于本病呈良性经过,具有特异的自身抗原抗体反应,对皮质类固醇激素有良好疗效,与系统性红斑狼疮(SLE),硬皮病(SD),皮肌炎(DM)有重叠现象,因而及时作出诊断并提高本病与其他结缔组织病相互关系的认识日益引人注目。迄今见诸于文献的已约有250例之多,实际上早年就有几种胶 Mixed connective tissue disease (Mixed Connective Tissue Disease referred to as MCTD) is an immune complex disease found in recent years, with similar to other connective tissue disease immunological changes, and thus belong to the category of systemic autoimmune diseases. Sharps was equal to the disease that was discovered in 1971, and was first reported and named in 1972, with more reported thereafter. Because the disease is benign, with a specific autoantigen antibody response, good effect on corticosteroids, and systemic lupus erythematosus (SLE), scleroderma (SD), dermatomyositis (DM) overlap, and thus Awareness of timely diagnosis and improvement of the relationship of this disease with other connective tissue diseases is attracting attention. So far in the literature has been about as many as 250 cases, in fact, there are several early gum