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1例84岁女性患者因冠状动脉粥样硬化性心脏病,口服辛伐他汀40 mg,1次/d。用药10余年,患者出现全身肌肉酸痛、无力。入院体格检查:肌紧张度增高,压痛明显。实验室检查示肌酸激酶(CK)4488 U/L,考虑为辛伐他汀所致横纹肌溶解症,遂停用辛伐他汀,其他治疗药物继续使用,给予口服辅酶Q10。12 d后复查,CK降至85 U/L。
A 84-year-old woman with coronary artery disease due to coronary heart disease, oral simvastatin 40 mg, 1 / d. Medication for more than 10 years, patients with systemic muscle soreness, weakness. Admission physical examination: increased muscle tone, tenderness significantly. Laboratory tests showed creatine kinase (CK) 4488 U / L, consider simvastatin induced rhabdomyolysis, then stop the use of simvastatin, other therapeutic drugs continue to be given oral coenzyme Q10.12 d after the review, CK Drop to 85 U / L.