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在胃肠道吸收过程中甲苯磺丁脲的水难溶性使其溶解速率成为限速因素,18种商品的体外溶出速率说明存在显著的差异。本研究目的主要观察甲苯磺丁脲与β-环糊精的作用、包合物的理化性质及扩散性能。取适量β环糊精与甲苯磺丁脲混合,加蒸馏水,在30±0.5℃振摇48小时后平衡6天,包合物成微晶析出,过滤,40℃真空干燥过夜。相溶解度试验说明,包合物的化学组成为甲苯磺丁脲:β环糊精(1:2)。在差热扫描及X衍射光谱中,甲苯磺丁脲的吸热峰完
The poor solubility of tolbutamide in the gastrointestinal tract during absorption led to a rate-limiting factor, with in vitro dissolution rates of 18 commodities indicating significant differences. The purpose of this study is to observe the role of tolbutamide and β-cyclodextrin, the physical and chemical properties of inclusion complexes and their diffusion properties. Take the appropriate amount of β-cyclodextrin and tolbutamide mixed, add distilled water, shake at 30 ± 0.5 ℃ 48 hours after the balance of 6 days, the inclusion compound crystallized, filtered, and dried at 40 ℃ under vacuum overnight. Phase solubility test shows that the chemical composition of clathrate is tolbutamide: β-cyclodextrin (1: 2). In differential scanning and X-ray diffraction, the endothermic peak of tolbutamide was completed