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目的探索米非司酮配伍米索终止中、晚期妊娠的效果。方法289例孕妇分为3组，孕13～16wk为Ⅰ组，孕16～27wk末为Ⅱ组，＞28wk为Ⅲ组。各组均在住院前第1、2天上午8时分别服米非司酮75mg，第3天上午8时住院服米索，首次剂量0．6mg，若无有效官缩，每小时加0.2mg,最大剂量≤16mg。结果组引产成功率分别为97．05％、93．16％、92．85％，3组间比较无显著性差异（P＞0．05）。各组服米索至胎儿排出的平均时间＜8h，规律宫缩至胎儿排出的平均时间＜5h。3组胎盘、胎膜残留率为32．53％，其中、Ⅱ、Ⅲ组占96．81％。立即清官者产后平均出血时间＜9d；未清宫者，产后平均出血时间＞32d。结论①米非司酮配伍米索用于中、晚期妊娠引产均有效。②中期妊娠引产胎盘、胎膜残留率较高，及时清宫是防止出血时间延长的有效措施。
Objective To explore the effect of mifepristone and misoprostol on termination of middle and late pregnancy. Methods 289 pregnant women were divided into three groups, pregnant 13 ~ 16wk group Ⅰ, 16-27 weeks pregnant Ⅱ group,> 28wk group Ⅲ. Each group were treated with mifepristone 75mg at 8:00 am on the first day and the second day before hospitalization. The first dose was 0.6 mg at 8:00 am on the third day. If there was no effective reduction, 0.2 mg , The maximum dose ≤ 16mg. Results The success rate of induction of labor was 97.05%, 93.16%, 92.85% respectively. There was no significant difference between the three groups (P> 0.05). The average time between misoprostol and fetus discharge was less than 8 hours, and the average time from contractions to fetus discharge was less than 5 hours. Three groups of placenta, fetal membrane residual rate of 32.53%, of which, Ⅱ, Ⅲ group accounted for 96.81%. Immediately after the officer of the average postpartum hemorrhage time <9d; who did not clear the palace, the average postpartum hemorrhage time> 32d. Conclusion ① mifepristone with misoprostol is effective in inducing labor in middle and late pregnancy. ② second trimester pregnancy induced abortion placenta, fetal membrane residual rate higher, timely clearance is to prevent bleeding time is an effective measure to extend.