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目的探讨不同时间的吸氧排氮方案对高空减压病的预防效果。方法 2 4只家兔随机分为对照组、吸氧排氮 30、60和 1 2 0min组 4组。麻醉后行机械通气 ,分别吸氧排氮 0、30、60和 1 2 0min后上升至 1 10 0 0m停留 30min ,用超声多普勒技术检测气泡产生情况。结果高空减压时气泡首次检出时间随着吸氧排氮时间的增加而延长 ,吸氧排氮 60min和 1 2 0min组家兔气泡首次检出时间较对照组显著延长 (P<0 .0 1 ) ,气泡首次检出时间与吸氧排氮时间呈正相关关系 (P <0 .0 1 ) ;累积气泡数随着吸氧排氮时间的增加而减少 ,吸氧排氮 60min和 1 2 0min组家兔累积气泡数较对照组显著减少 (P <0 .0 1 ) ,累积气泡数与吸氧排氮时间呈负相关关系 (P <0 .0 1 )。结论吸氧排氮 60min和 1 2 0min两种方案可以显著减少兔由地面上升到 1 1 0 0 0m高空减压时气泡的产生。
Objective To investigate the preventive effects of oxygen-releasing and nitrogen-releasing programs on altitude decompression sickness at different times. Method 2 4 rabbits were randomly divided into control group, oxygen inhalation nitrogen 30,60 and 120 min 4 groups. Mechanical ventilation was performed after anesthesia, and the oxygen evacuation rate was increased to 10 000 m after 30 min, 30 min and 120 min, respectively, and the air bubble was detected by ultrasound Doppler. Results The first time of air bubble detection at altitude was prolonged with the increase of oxygen and nitrogen release time. The first time of air bubble detection in rabbits in 60min and 120min groups was significantly longer than that in control group (P <0. 0) 1). The time of first detection of air bubbles was positively correlated with the duration of oxygen release and nitrogen release (P <0.01). The number of accumulated air bubbles decreased with the increase of oxygen and nitrogen release time, Compared with the control group, the cumulative number of bubbles in the rabbits in the group of rabbits decreased significantly (P <0.01). The number of accumulated bubbles was negatively correlated with the duration of oxygen release and nitrogen release (P <0.01). Conclusions Both the 60 min and 120 min oxygen abatement treatments can significantly reduce the bubble generation when the rabbit is elevated from the ground to 11 000 m altitude.