论文部分内容阅读
目的探讨晚期胰腺癌患者三维适形放射疗法联合热疗的临床疗效。方法采用三维适形放疗联合热疗技术对50例晚期胰腺癌患者进行治疗。对于直径<5 cm的肿瘤,每周放疗3次,每次3.8～4.5 Gy,4周总剂量为45～54 Gy;对于直径>5 cm的肿瘤,每周放疗5次,每次2 Gy,6周总剂量为60～65 Gy。对全部患者在放疗后1 h内进行热疗。结果患者在治疗后2～3个月进行CT检测复查,治疗后总有效率达70.0%,腹痛总缓解率为100%,黄疸总消退率84.6%。治疗后两年随访结果表明,生存率为60.0%。结论采用三维适形放疗与热疗联合治疗晚期胰腺癌的疗效好,不良反应小,止痛效果好,值得临床推广。
Objective To investigate the clinical effect of three-dimensional conformal radiotherapy combined with hyperthermia in patients with advanced pancreatic cancer. Methods 50 cases of patients with advanced pancreatic cancer were treated with three-dimensional conformal radiotherapy and hyperthermia. For tumors <5 cm in diameter, radiotherapy was performed three times per week for 3.8-4.5 Gy, with a total dose of 45-54 Gy for 4 weeks, and 5 Gy per week for tumors> 5 cm in diameter for 2 Gy each. The total dose for 6 weeks was 60-65 Gy. All patients were treated with hyperthermia within 1 h after radiotherapy. Results The patients underwent CT examination 2 to 3 months after treatment. The total effective rate was 70.0% after treatment, the total remission rate of abdominal pain was 100% and the total rate of remission of jaundice was 84.6%. Follow-up two years after treatment showed that the survival rate was 60.0%. Conclusion Three-dimensional conformal radiotherapy combined with hyperthermia in the treatment of advanced pancreatic cancer has good curative effect, small adverse reaction and good analgesic effect, which deserves clinical promotion.