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目的探讨1HMRS在星形细胞肿瘤分级和鉴别诊断中的价值。方法星形细胞肿瘤58例,包括弥漫性星形细胞瘤18例,间变性星形细胞瘤24例,胶质母细胞瘤16例,均行常规MR和1HMRS检查,统计分析Cho/Cr、Cho/NAA及NAA/Cr比值。结果弥漫性星形细胞瘤表现为Cho轻度升高,NAA和Cr轻度下降,未出现Lac。间变性星形细胞瘤和胶质母细胞瘤均表现为Cho明显升高,NAA及Cr明显下降,6例出现Lac。弥漫性星形细胞瘤Cho/NAA比值为2.72±1.16,Cho/Cr比值为2.66±1.21,NAA/Cr比值为1.02±0.34。间变性星形细胞瘤Cho/NAA比值为5.69±1.32,Cho/Cr比值为4.92±1.46,NAA/Cr比值为0.92±0.16。胶质母细胞瘤Cho/NAA比值为5.71±1.08,Cho/Cr比值为5.12±1.76,NAA/Cr比值为0.87±0.13。结论1HMRS对星形细胞肿瘤分级和鉴别诊断很有价值。
Objective To investigate the value of 1H MRS in the classification and differential diagnosis of astrocytic tumors. Methods Fifty-eight patients with astrocytic tumors including 18 diffuse astrocytomas, 24 anaplastic astrocytoma and 16 glioblastoma were examined by routine MR and 1H MRS. The statistical analysis of Cho / Cr, Cho / NAA and NAA / Cr ratio. Results Diffuse astrocytoma showed mild increase of Cho, slight decrease of NAA and Cr, no appearance of Lac. Anaplastic astrocytoma and glioblastoma showed Cho increased significantly, NAA and Cr decreased significantly, 6 cases of Lac. Cho / NAA ratio of diffuse astrocytoma was 2.72 ± 1.16, Cho / Cr ratio was 2.66 ± 1.21, NAA / Cr ratio was 1.02 ± 0.34. Cho / NAA ratio was 5.69 ± 1.32, Cho / Cr ratio was 4.92 ± 1.46, and NAA / Cr ratio was 0.92 ± 0.16. Cho / NAA ratio of glioblastoma was 5.71 ± 1.08, Cho / Cr ratio was 5.12 ± 1.76, NAA / Cr ratio was 0.87 ± 0.13. Conclusion 1HMRS is valuable for the classification and differential diagnosis of astrocytic tumors.