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目的探讨成人隐匿性自身免疫性糖尿病(LADA)与2型糖尿病(T2DM)患者的生物心理因素的异同及其与血糖控制的相关关系。方法用病例-对照的研究方法分析LADA与T2DM患者抑郁的情感因素差异及其与血糖控制的关系。结果 LADA患者抑郁症的患病率较T2DM患者明显增加;HAMD量表评分比较,除日夜变化评分外,其余变量在LADA患者均显著高于T2DM患者;LADA合并抑郁症患者的HAMD评分较T2DM中抑郁症患者HAMD评分显著增高;LADA患者较T2DM患者的脆性糖尿病发生率明显增加;LADA合并抑郁症的患者与LADA未合并抑郁症的患者出现脆性糖尿病的风险差异无统计学意义(P>0.05)。结论 LADA患者抑郁症的患病率及其病情严重程度均较T2DM患者增加,LADA患者患抑郁症与否与发生脆性糖尿病风险无明显相关性,抑郁症未增加LADA患者出现脆性糖尿病的风险。
Objective To investigate the similarities and differences of biopsychological factors in patients with latent autoimmune diabetes (LADA) and type 2 diabetes mellitus (T2DM) between adults and their relationship with glycemic control. Methods The case-control study was used to analyze the relationship between depression and mood factors in patients with LADA and T2DM and their relationship with glycemic control. Results Compared with T2DM patients, the prevalence of depression in LADA patients was significantly higher than that in T2DM patients. The scores of HAMD scale were significantly higher in patients with LADA than those in T2DM except for the day and night scores. The HAMD scores of LADA patients with depression were significantly lower than those of T2DM The HAMD score of depression patients was significantly higher than that of T2DM patients. The incidence of fragility diabetes in LADA patients was significantly higher than that of T2DM patients. There was no significant difference in the risk of brittle diabetes between LADA patients with depression and those without LADA (P> 0.05) . Conclusions The prevalence and severity of depression in patients with LADA are higher than those in patients with T2DM. There is no significant correlation between depression and risk of developing diabetes in patients with LADA. Depression does not increase the risk of developing brittle diabetes in patients with LADA.