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[目的 /意义]厘清转化研究测度与评估的基础理论和方法体系,推动我国转化医学评估体系的建立和基于证据的转化医学科技政策的制定以及转化医学项目、机构的科学管理。[方法 /过程]对Web of Science和Pub Med收录的有关转化研究测度与评估的文献进行综述,对美国、英国提出的转化医学评估体系进行案例分析。[结果 /结论]国际上对转化研究的测度和评估主要包括两方面:一是微观层面的基于转化研究全谱段上不同属性的研究活动之间的引用网络分析或数据关联分析测度转化研究过程;二是宏观层面的转化研究影响力与绩效评估。目前转化研究的概念包括T模型和过程模型两种,前者强调转化研究的阶段和基本要素,适于从微观层面对转化研究过程进行测度;后者强调转化研究的关键步骤和里程碑式成就,适于从宏观层面对转化医学研究机构、相关专项计划或基金资助绩效进行评估。现阶段我国的转化医学应重视“在国际已有成果基础上开展转化研究”的模式,在我国重视发展转化医学的背景下,加强对具体医学领域转化研究过程的测度分析、对适合我国转化医学发展的科研成果评价体系以及转化医学研究中心绩效评估体系的研究。
[Purpose / Significance] To clarify the basic theories and methodologies for the measurement and evaluation of translation studies, and to promote the establishment of China’s translational medicine evaluation system and the establishment of evidence-based medical science and technology policies for translational medicine, as well as the scientific management of translational medicine projects and institutions. [Methods / Procedures] This review summarizes the literature on measurement and evaluation of translational studies included in Web of Science and Pub Med, and provides case studies on translational medical evaluation systems proposed by the United States and the United Kingdom. [Results / Conclusions] The measurement and evaluation of translational research in the world mainly include two aspects: one is the micro-level reference between the research activities based on the different attributes of the translational study; the network analysis or the data correlation analysis; ; Second, the impact of macro-level translation research and performance evaluation. At present, the concept of transformation research includes two models: T model and process model. The former emphasizes the stages and basic elements of transformation research, and is suitable for measuring the transformation research process at the micro level. The latter emphasizes the key steps and milestone achievements of transformation research. At the macro level, we will evaluate the performance of translational medicine research institutes, relevant special programs or fund grants. At this stage, translational medicine in China should pay attention to the mode of “transformational research on the basis of international achievements”, and in the context of our country’s emphasis on the development of translational medicine, to strengthen the measurement and analysis of the transformational research process in specific fields of medicine, Study on the Evaluation System of Scientific Research Achievements for Translational Medicine and the Performance Evaluation System of Translational Medicine Research Center.