目的探讨六联疗法(福辛普利、坎地沙坦、利尿剂、地高辛、卡维地洛、曲美他嗪)治疗充血性心力衰竭的疗效和安全性。方法选择40例心功能Ⅱ～Ⅲ级的充血性心力衰竭患者,全部接受六联疗法,治疗12个月,以自身作为对照比较治疗前后患者心功能的变化,评估临床有效性和安全性。结果随访12个月,全部心衰患者的心功能治疗前明显改善(P<0.05),12个月后有效率100%。结论六联疗法明显改善心衰患者的心功能,提高生活质量和生存率。 Objective To investigate the efficacy and safety of six combined therapies (fosinopril, candesartan, diuretics, digoxin, carvedilol and trimetazidine) in the treatment of congestive heart failure. Methods Forty patients with congestive heart failure of grade Ⅱ ~ Ⅲ were enrolled in this study. All patients were treated with six combined therapy for 12 months. The changes of cardiac function before and after treatment were compared with each other to evaluate the clinical efficacy and safety. Results All cases were followed up for 12 months. The heart function of all patients with heart failure was significantly improved before treatment (P <0.05), and the effective rate was 100% after 12 months. Conclusion Six-combined therapy significantly improves cardiac function, improves quality of life and survival rate in patients with heart failure.