论文部分内容阅读
本研究结果表明,沙土鼠急性脑缺血时皮层与下丘脑β-内啡肽含量明显升高,强啡肽A含量无明显变化;侧脑室注射强啡肽A、纳洛酮和抗β-内啡肽血清可减轻脑水肿,注射β-内啡肽可加重脑水肿。这提示β-内啡肽与强啡肽A参与急性脑缺血病理过程,两者在缺血性脑水肿的形成和发展过程中具有相互的作用。本研究为脑卒中的临床治疗提供了新实验依据。
The results of this study showed that the contents of β-endorphin in the cortex and hypothalamus were significantly increased in gerbils with acute cerebral ischemia and the contents of dynorphin A were not changed. Intracerebroventricular injection of dynorphin A, naloxone and anti- Endorphin serum can reduce cerebral edema, injection of β-endorphin can increase cerebral edema. This suggests that β-endorphin and dynorphin A are involved in the pathogenesis of acute cerebral ischemia, both of which play a role in the formation and development of ischemic brain edema. This study provides a new experimental basis for the clinical treatment of stroke.