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1 概述单纯疱疹病毒(herpes simplex virus,HSV)是人类最常见的病原体之一,有两个血清型:HSV-1和HSV-2.HSV-1主要侵犯躯体腰以上部位;HSV-2侵及躯体腰以下部位,主要在生殖器.目前生殖器HSV感染发病率不断上升,在某些西方国家已跃居性病常见病因的第二位.孕妇由于孕期孕激素变化,可能抑制细胞介导免疫,而易于感染HSV.母亲孕期HSV感染可传播给新生儿.多为HSV-2所引起.新生儿HSV感染的临床表现既可以是局部的,也可以是播散性的,病情较重,病死率高,幸存者往往有终身残疾。因此.对围生期该病毒感染的发病机理和免疫的研究将有助于我们对该病毒感染的认识,对围生期单纯疱疹病毒感染的早期诊断、早期治疗提供积极有益的帮助。
1 Overview Herpes simplex virus (HSV) is one of the most common human pathogens and has two serotypes: HSV-1 and HSV-2. HSV-1 mainly invades the upper body’s waist. HSV-2 is The body below the waist, mainly in the genitals.The current incidence of genital HSV infection rising, in some Western countries has risen to the second most common cause of sexually transmitted diseases.Pregnant women due to pregnancy progesterone changes may inhibit cell-mediated immunity, and easy HSV infection in mothers during pregnancy can be transmitted to the newborn HSV-2, mostly caused by HSV-2.The clinical manifestations of neonatal HSV infection can be localized, it can be disseminated, severe illness, high mortality, Survivors often have life-long disabilities. Therefore, the research on the pathogenesis and immunity of this virus infection during perinatal period will help us to recognize the viral infection and provide positive and helpful help for the early diagnosis and early treatment of perinatal herpes simplex virus infection.