论文部分内容阅读
目的：观察单纯性疱疹病毒（ＨＳＶ）在食管癌组织中的分布并探讨其与食管癌的关系。方法：对５２ 例食管癌石蜡包埋组织用免疫组化和原位杂交技术进行定位观察。结果：癌组织ＨＳＶ 免疫组化阳性率ＨＳＶ１ 为５３－８ ％ ，ＨＳＶ２ 为５７－７％ ；癌旁食管粘膜ＨＳＶ 为６５－５ ％ ，其中ＨＳＶ１（１２／２９）４１％ ，ＨＳＶ２（１６／２９）５５－２％ 。原位杂交癌阳性率为５３－８ ％ ，癌旁粘膜为５８－６％ 。ＨＳＶ 阳性率与癌组织的分化程度和淋巴结转移相关（ Ｐ＜ ０－０５） ，但与癌组织间质淋巴细胞浸润的强度无关（ Ｐ＞０－０５）。结论：ＨＳＶ感染可能影响食管癌的分化和癌细胞的生物学特性。
Objective: To observe the distribution of herpes simplex virus (HSV) in esophageal cancer and explore its relationship with esophageal cancer. Methods: 52 paraffin-embedded tissues of esophageal cancer were observed by immunohistochemistry and in situ hybridization. RESULTS: The positive rates of HSV immunohistochemistry in cancer tissues were 53-8 % for HSV-1 and 57-7% for HSV-2, and 65-5 % for para-aortic mucosal HSV, of which HSV-1 (12/29) 41%. HSV 2 (16/29) 55-2%. The positive rate of in situ hybridomas was 53-8 %, and paraneoplastic mucosa was 58-6%. The positive rate of HSV was related to the degree of differentiation and lymph node metastasis (P 0-05), but it was not related to the intensity of lymphocyte infiltration of cancer tissue (P 0-05). Conclusion: HSV infection may affect the differentiation of esophageal cancer and the biological characteristics of cancer cells.