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目的探讨重庆市儿童哮喘与肥胖发病风险的关联程度,为临床诊治提供参考依据。方法采用病例对照研究,共纳入6~13岁的120名哮喘儿童及240名非哮喘儿童作为研究对象,对研究对象进行体格检查及问卷调查、血液学检测。结果与正常对照组相比,体质指数(body mass index,BMI)的升高可增加儿童哮喘发病风险(t=8.64,P=0.000);二手烟暴露史与哮喘发病风险呈正相关(χ~2=7.38,P=0.007)。哮喘组肥胖人群的胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、C反应蛋白水平均高于正常体重组(P值均<0.05)。结论儿童BMI及血脂谱、C反应蛋白水平的升高均可增加哮喘的发病风险。
Objective To explore the correlation between childhood asthma and the risk of obesity in Chongqing and to provide a reference for clinical diagnosis and treatment. Methods A case-control study was conducted. A total of 120 asthmatic children aged 6-13 years and 240 non-asthmatic children were enrolled in this study. Physical examination, questionnaire and hematology tests were performed on the subjects. Results Compared with the normal control group, the increase of body mass index (BMI) increased the risk of asthma in children (t = 8.64, P = 0.000). The history of secondhand smoke exposure was positively correlated with the risk of asthma (χ ~ 2 = 7.38, P = 0.007). The levels of cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, and C-reactive protein in obese subjects with asthma were higher than those in normal subjects (P <0.05). Conclusion Children with BMI and lipid profile, elevated C-reactive protein levels may increase the risk of asthma.