自身免疫性疾病是西方社会一直未能有效解决的棘手问题 ,但最近发现人抗体是一类可以有效治疗该疾病的药物。一些自身免疫性疾病 ,例如类风湿性关节炎 ,在用人抗体治疗过程中取得显著疗效。人抗体治疗剂的产生方法中最常用的是噬菌体展示和转基因小鼠技术 ,最近又出现无细胞展示技术。本文介绍了几种产生抗体的方法 ,并探讨了其中几种方法在治疗自身免疫性疾病方面的潜在优势。 Autoimmune diseases are a thorny problem that western society has not been able to effectively solve. However, human antibodies have recently been found to be a type of drug that can effectively treat the disease. Some autoimmune diseases, such as rheumatoid arthritis, achieve significant efficacy in the treatment of human antibodies. The most commonly used methods for the production of human antibody therapeutics are phage display and transgenic mouse technology, and recently cell-free display technology has emerged. This article describes several ways to produce antibodies and explores the potential benefits of several of these in the treatment of autoimmune diseases.