紫杉醇(Taxol)是天然抗癌药物,已在临床上广泛使用,市场需求量大,由于生产原料的制约,供需之间存在巨大缺口,价格仍然昂贵。利用真菌发酵生产紫杉醇是解决药源的一条新途径。对产紫杉醇内生真菌的多样性,紫杉醇真菌的采集鉴定、真菌紫杉醇提取和测定的一些经验,紫杉醇真菌分子生物及生物合成代谢研究进展等进行了综述。 Taxol is a natural anti-cancer drug which has been widely used clinically. Due to the large market demand, due to the restriction of raw materials for production, there is a huge gap between supply and demand, and the price is still expensive. The use of fungal fermentation of paclitaxel is a new way to solve the drug source. The taxol endophytic fungi diversity, taxol fungi collection and identification, fungal taxol extraction and determination of some experience, taxol fungal molecular biology and biosynthetic metabolism research are reviewed.