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目的探讨奥曲肽治疗肝硬化合并上消化道出血的临床疗效。方法选取2010年12月—2014年8月于宁德市屏南县医院收治的肝硬化合并上消化道出血患者106例,采用随机法分为对照组与观察组,每组53例。对照组患者予以垂体素治疗,观察组患者在常规治疗基础上予以奥曲肽治疗,比较两组患者临床疗效、生活质量和心理量表(QLQC30)评分及不良反应发生情况。结果观察组总有效率高于对照组(P<0.05)。观察组患者躯体、心理、社会、认知功能评分及总分高于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论奥曲肽治疗肝硬化合并上消化道出血的临床疗效确切,可有效改善患者临床症状,提高生活质量,且安全性高。
Objective To investigate the clinical efficacy of octreotide in the treatment of liver cirrhosis complicated with upper gastrointestinal bleeding. Methods From December 2010 to August 2014, 106 patients with cirrhosis and upper gastrointestinal hemorrhage admitted to Pingnan County Hospital of Ningde were randomly divided into control group and observation group, with 53 cases in each group. Patients in the control group were treated with pituitary hormone. The patients in the observation group were treated with octreotide on the basis of conventional treatment. The clinical efficacy, quality of life and psychological scale (QLQC30) scores and the incidence of adverse reactions were compared between the two groups. Results The total effective rate in observation group was higher than that in control group (P <0.05). The physical, mental, social, cognitive function score and total score of the observation group were higher than those of the control group (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion The clinical efficacy of octreotide in the treatment of liver cirrhosis complicated with upper gastrointestinal bleeding is accurate, which can effectively improve the clinical symptoms and improve the quality of life of patients with high safety.