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目前已证明胃肠道神经元中存在有蛙皮素类免疫(BLI)。这可能是胃肠道肽能神经递质系统的一部分。该系统在调节胃的外分泌、内分泌和运动功能等方面可能起一定作用。以前的研究认为胃的BLI释放是由乙酰胆硷(Ach)和肽能神经递质兴奋所引起。由于发现了具有阿片活性的肽类,如亮氨酸脑啡肽也存在于胃肠道的植物神经系统中,故作者就外源性和内源性阿片类对胃BLI分泌的影响进行研究。用Kerb-Ringer氏缓冲液灌流经过整夜禁食的大鼠胃。该溶液中含有100mg％葡萄糖。流出物通过肝门静脉收集。用特异性抗Lys~4一蛙皮
It has been demonstrated that there is a bombesin immunization (BLI) in gastrointestinal neurons. This may be part of the gastrointestinal peptide neurotransmitter system. The system may play a role in regulating the gastric secretion, endocrine and motor function. Previous studies have suggested that gastric BLI release is caused by the excitation of acetylcholine (Ach) and the peptide neurotransmitter. Since the discovery of opioid peptides such as Leu-enkephalin is also present in the autonomic nervous system of the gastrointestinal tract, the authors investigated the effects of exogenous and endogenous opioids on gastric BLI secretion. Rat stomach overnight fasted was perfused with Kerb-Ringer’s buffer. The solution contains 100 mg% glucose. The effluent is collected through the hepatic portal vein. Use a specific anti-Lys ~ 4 a frog skin