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目的 :检测不同肝病患者的血清IV型胶原含量 ,以判断其在肝硬化诊断中的应用。方法 :用双抗夹心酶免疫法进行测定。结果 :在各种肝病中血清IV型胶原含量均有不同程度升高 ,其中5 8.3%的慢活肝、86 .4 %的肝硬化组血清IV型胶原含量明显升高 ,与正常对照组有显著性差异 (P<0 .0 1)。结论 :血清IV型胶原的测定可作为肝硬化较好的诊断指标
Objective: To detect the serum level of type IV collagen in patients with different liver diseases to determine its application in the diagnosis of liver cirrhosis. Methods: The double antibody sandwich enzyme immunoassay was used. Results: The serum levels of type IV collagen in various liver diseases increased to different extents, of which, 8.3% of slow-living liver and 86.4% of cirrhotic patients had significantly increased serum type IV collagen, compared with the normal control group Significant difference (P <0. 01). Conclusion: The determination of serum type IV collagen can be used as a good diagnostic indicator of cirrhosis