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本文以同期死亡并行尸检的非老年重症肝病多器官功能衰竭（ＭＯＦ）患者８６例为对照，总结了３２例老年重症肝病患者ＭＯＦ的临床及尸检病理特点。结果表明，发生ＭＯＦ的主要诱因为感染及消化道出血。器官衰竭发生的顺序为肝、脑、肾、胃肠道、血液、心肺等。同时，肝脏有不同程度的肝细胞坏死，其他脏器可出现不同的病理改变，其中肺出血、心内膜及心外膜下出血、心肌断裂等发生率明显低于非老年组（Ｐ＜０．０５），而肾小球硬化、间质性肾炎的发生率明显高于非老年组（Ｐ＜０．０５）。老年重症肝病并发ＭＯＦ，应加强肝病的治疗，及时消除感染、消化道出血等诱发因素。
In this paper, 86 cases of non-elderly patients with severe liver disease and multiple organ failure (MOF) undergoing concurrent autopsy were enrolled in this study. The clinical and autopsy features of MOF in 32 elderly patients with severe liver disease were summarized. The results show that the main causes of MOF infection and gastrointestinal bleeding. Organ failure occurs in the order of liver, brain, kidney, gastrointestinal tract, blood, heart and lungs. At the same time, the liver has varying degrees of necrosis of liver cells, and other pathological changes may occur in other organs. The incidence of pulmonary hemorrhage, endocardial and epicardial hemorrhage, myocardial rupture, etc. were significantly lower than those in the non-elderly group (P <0 .05), while the incidence of glomerular sclerosis and interstitial nephritis was significantly higher than that of non-elderly group (P <0.05). Senile severe liver disease complicated with MOF should be to strengthen the treatment of liver disease, timely elimination of infection, gastrointestinal bleeding and other triggers.