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目的研究功能性消化不良（ＦＤ）患者胃膨胀感知的改变。方法应用灌注导管测压仪研究了７例ＦＤ患者、５例ＦＤ并心理异常患者及５例正常人胃对容量刺激的感觉。结果发现ＦＤ患者胃对容量刺激的最低敏感性阈值、不适阈值及疼痛阈值分别为（１９５．７±６５．３），（３０４．３±５８．６），（４６４．３±４７．２）ｍｌ，ＦＤ并心理异常患者为（１２３．０±４０．３），（２５４．０±４９．８），（４６６．０±７６．４）ｍｌ，均明显低于正常人的（３２７．０±４４．７），（５３２．４ ±１０７．４），（６７８．０±１１７．４）ｍｌ（Ｐ＜０．０１）；三者的胃顺应性无明显改变。结论胃对容量刺激的感知过度敏感是ＦＤ发病的机制之一。
Objective To investigate the changes of gastric distention perception in patients with functional dyspepsia (FD). Methods Perfusion catheter manometry was used to study the gastric sensation of volume stimulation in 7 FD patients, 5 FD patients with abnormal psychology and 5 normal persons. The results showed that the lowest sensitivity threshold, discomfort threshold and pain threshold of FD patients were (195.7 ± 65.3), (304.3 ± 58.6), (464.3 ± 47.2) ml, the average number of patients with FD and psychological abnormalities was (123.0 ± 40.3), (254.0 ± 49.8) and (466.0 ± 76.4) ml, respectively, which were significantly lower than that of normal subjects ± 44.7), (532.4 ± 107.4) and (678.0 ± 117.4) ml respectively (P <0.01). There was no significant difference in gastric compliance between the three groups. Conclusion One of the mechanisms of FD pathogenesis is excessive sensation of stomach to volume stimulation.