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作者检测了148例胃癌患者的血清标本,发现AFP阳性(AFP>20ng/ml)8例(5.4％)。其中AFP>400ng/ml者5例。平均年龄57岁,瘤体在胃窦部占6例,平均直径7.6cm,呈Borr-mannⅡ、Ⅲ型7例。Ⅳ期5例。肝转移5例(62.5％)。死亡5例平均生存期不到10个月。组织学检查中-高分化管状腺癌占7例。说明AFP阳性胃癌具有年龄偏大,胃窦部BorrmannⅡ、Ⅲ型为主,瘤体大,病期晚,组织学分化程度高的腺癌多见。肝转移率高,预后差为其特点。AFP检测、动态观察在胃癌诊治中有其重要意义。
The authors detected serum samples from 148 patients with gastric cancer and found that AFP was positive (AFP> 20 ng/ml) in 8 patients (5.4%). Among them, 5 cases had AFP>400ng/ml. The average age was 57 years old. The tumor volume accounted for 6 cases in the gastric antrum with an average diameter of 7.6 cm. It was Borr-mann II and III in 7 cases. IV period 5 cases. Liver metastases occurred in 5 patients (62.5%). The average survival time of 5 deaths was less than 10 months. Histological examination - 7 cases of well-differentiated tubular adenocarcinoma. It was shown that AFP-positive gastric cancer was older, with Borrmann II and III type mainly in gastric antrum, large tumor size, and late stage of disease. Adenocarcinoma with high degree of histological differentiation was more common. The liver metastasis rate is high, and the poor prognosis is its characteristic. AFP detection and dynamic observation have important significance in the diagnosis and treatment of gastric cancer.