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目的分析HBV-DNA阳性患者乙型肝炎病毒血清标志物(HBVM)的检测结果,探讨其临床意义。方法对吉林大学中日联谊医院体检的乙型肝炎患者血清,用荧光定量PCR方法检测HBV-DNA,ELISA法检测HBVM。结果在280例HBV-DNA阳性患者中,共检出13种血清标志物模式,其中HBsAg阳性的模式有272例,HBsAg阴性的模式有8例。结论各种HBVM模式均有可能检出HBV-DNA,HBV-DNA是HBV感染更为直接、灵敏和特异的指标。
Objective To analyze the detection results of hepatitis B virus (HBVM) in HBV-DNA positive patients and explore its clinical significance. Methods The serum of hepatitis B patients who were physical examination at Sino-Japanese Friendship Hospital of Jilin University was detected by fluorescence quantitative PCR and HBVM by ELISA. Results Of 280 HBV-DNA positive patients, 13 serum markers were detected, of which 272 were HBsAg-positive and 8 were HBsAg-negative. Conclusion All kinds of HBVM patterns are likely to detect HBV-DNA, HBV-DNA is a more direct, sensitive and specific indicators of HBV infection.