论文部分内容阅读
目的 应用冰水灌胃方法建立了大鼠新概念便秘型IBS模型 ,研究该模型结肠、脊髓背角与边缘系统 5 羟色胺 (5 hydroxytryptamine ,5 HT)、c fos的表达 ,进一步阐明IBS大鼠模型可能的 5 HT能神经传导通路异常。方法 出生后 4周Wistar大鼠 5 0只随机分为 3组 :冰水灌胃组 (A
Objective To establish a new constipation model of IBS in rats by using ice-water gavage to study the expression of 5-hydroxytryptamine (5 HT) and c fos in the colon, spinal dorsal horn and limbic system of the model, and further elucidate the IBS rat model Possible 5 HT nerve conduction pathway abnormalities. Methods Forty Wistar rats were randomly divided into three groups at 4 weeks after birth: