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十二指肠溃疡是一种治后容易复发的疾病。短期服用西咪替丁、甲硝呋胍等抑酸剂类抗溃疡药,虽有一定效果,但一般认为这种效果并不持久,一旦停药后,有90％以上的患者在6个月以内溃疡复发。最近 Sephen Sontag 等报道,将服用西咪替丁的病人分为200mg,1天2次;300mg,1天2次及睡前400mg 等3组,连续服药一年,溃疡的复发率明显减少。这3组不同给药法的复发率几乎无明显差异,分别为19％、15％、13％。但是这3组与安慰剂组比较有显著差异,后者为34.7％。此
Duodenal ulcer is a disease easy to relapse after treatment. Short-term use of cimetidine, anti-acid drugs such as ginseng furosemide and anti-ulcer drugs, although a certain effect, but generally believed that this effect is not lasting, once discontinued, more than 90% of patients in 6 months Ulcer recurrence within. Recently, Sephen Sontag et al reported that patients taking cimetidine were divided into 200mg twice a day; 300mg, twice a day and 400mg at bedtime and other three groups. One year of continuous administration, the recurrence rate of ulcer was significantly reduced. There was almost no significant difference in the recurrence rates among these three groups, which were 19%, 15% and 13%, respectively. However, there was a significant difference between these 3 groups and the placebo group, with 34.7% for the latter. this